The topics of the symposium will include:

Topic 1: Nitric oxide, mutagenesis, carcinogenesis, tumor promotion and tumor growth

The chemistry of nitric oxide and its metabolites in cells, normal and cancerous, will be discussed. The role of nitric oxide in regulating carcinogenesis, tumor promotion and tumor growth will be presented both in experimental and in clinical studies.


Topic 2: Nitric oxide regulation of cell death pathways

The induction of nitric oxide in various cancer tissues has been shown to be involved in the regulation of tumor cell sensitivity to apoptosis by regulating the apoptotic pathways. In addition, the role of nitric oxide as a chemo-immuno-sensitizing agent will be discussed.


Topic 3: Nitric oxide: proliferation and epithelial-mesenchymal transition

Recent studies have reported that nitric oxide is involved in the regulation of the epithelial mesenchymal transmission (EMT) and metastasis by regulating various gene products involved in EMT. The underlying mechanisms will be discussed.


Topic 4: Regulation of immune response by nitric oxide

Several reports have indicated that nitric oxide plays a role in the regulation of the immune response. Discussions will be centered on the mechanisms as well as on the role of nitric oxide in normal immune responses and autoimmunity.


Topic 5: Antitumor activity of nitric oxide-based releasing strategies: pre-clinical and clinical studies

Preclinical studies will be reported to discuss by what mechanisms both the induction of nitric oxide and/or the use of nitric oxide donors may be applied as novel therapeutics for resistant cancers, used either alone or in combination with current therapeutics.


Topic 6: Novel nitric oxide donors synthesis

The synthesis and biological activity of novel small nitric oxide donors will be discussed. In particular, NO donors able to release NO under light and/or ultrasound irradiation will be presented.


Topic 7: Nanoparticles mediated release of NO donors and multi-modal treatment

The preparation and biological activity of nanoparticles able to provide multiple drugs release, including nitric oxide, will be presented. In particular, attention will be paid to those systems able to carry chemotherapeutic drugs and NO-donors with synergistic cytotoxic effect on cancer.